Quantifying smoking exposure, genomic correlates, and related risk of treatment failure in p16+ squamous cell carcinoma of the oropharynx.

Laryngoscope Investig Otolaryngol · 2021 · PMC8665424 · PMID 34938877

Europe PMC DOI

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a strong trendno p-value reported

A strong trend was observed for increased C to A transversion mutations above 25 pack‐years, which are known to be associated with exposure to tobacco smoke.

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did not achieve significanceno p-value reported

In addition, there was a trend toward worse RFS in patients with any smoke exposure as compared to never‐smokers, although this did not achieve significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.