Methylation of <i>BDNF</i> and <i>SLC6A4</i> Gene Promoters in Brazilian Patients With Temporal Lobe Epilepsy Presenting or Not Psychiatric Comorbidities.

Front Integr Neurosci · 2021 · PMC8667271 · PMID 34912196

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showed a trendno p-value reported

(2008) , using samples from the Iowa Adoption Studies cohort, provided evidence that increased methylation levels in CpG islands overlapping with the transcriptional start site of SLC6A4 was associated with decreased levels of mRNA, and those with the 5-HTTLPR s allele showed a trend toward higher methylation levels across CpG sites located in this upstream island.

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