WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer.

Although the results did not quite reach significance due to the limited number of patient samples, the results do indicate that WNT11/ROR2 exerts an unfavorable role in brain metastasis of breast cancer patients in vivo.

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Since the increase in RHOA levels in BT-474 pROR2 cells was rather mild and did not reach statistical significance, we additionally measured the active GTP-bound form of RHOA by ELISA in this cell line (Fig. 2 c).

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