Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2<sup>hi</sup> Osteoclast Progenitors to the Affected Bone.

Front Immunol · 2021 · PMC8677701 · PMID 34925336

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Treatments showed a trend of reduced activation of CatK by functional osteoclasts, estimated by scanning of intact mice ( Figure 8E ) or dissected hind limbs (not shown) with similar results.

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