Sialomucin CD43 Plays a Deleterious Role in the Development of Experimental Heart Failure Induced by Pressure Overload by Modulating Cardiac Inflammation and Fibrosis.

Although CD43−/− TAC mice trended to develop more fibrosis than CD43−/− Sham mice, these differences did not reach statistical significance. qRT-PCR data analysis from heart lysates also showed significantly lower levels of Collagen Ia1 and Collagen IIIa1 gene expression in CD43−/− TAC hearts as compared to the levels seen in WT TAC hearts ( Figure 2E ).

also in 111,027 other papers