Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome.

Front Neurosci · 2021 · PMC8678485 · PMID 34924931

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0950

boldest claim

The sentences

marginally significantp = 0.053so close (0.05 < p ≤ 0.1)

On the ladder walk test, a poisson regression revealed a marginally significant effect of treatment ( z = 1.93, p = 0.053) based on genotype ( z = 2.08, p = 0.038).

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did not reach statistical significancep = 0.095so close (0.05 < p ≤ 0.1)

There was no significant effect of genotype on the total number of BrdU + /NeuN + double-labeled cells in the dentate gyrus ( Figure 4E ), classified as adult proliferating neurons (i.e., adult neurogenesis), and the effect of AlloP treatment on BrdU + /NeuN + double-labeled cells did not reach statistical significance ( z = −1.67, p = 0.095).

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