Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis.

BMC Med · 2021 · PMC8680114 · PMID 34915885

Europe PMC DOI

hedged sentences

0.0650

closest p · 1.3× alpha

0.0650

boldest claim

The sentences

marginally significantp = 0.065so close (0.05 < p ≤ 0.1)

The difference in the response rate between the two groups was marginally significant ( z = 1.85, p = 0.065), with a positive (favouring active treatment) overall effect size OR = 1.525 (95% CI 0.975–2.385) and no evidence suggesting heterogeneity ( I 2 = 0.0%, Q = 10.84, p = 0.457).

also in 26,082 other papers

a significant trendno p-value reported

The therapy of tDCS + SSRIs only showed consistently positive effects, significantly bigger improvement, and a higher response rate with a significant trend (Additional file 7 : Figure.

also in 9,775 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.