S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca<sup>2+</sup> signaling by Jurkat T cell receptors at the immune synapse.

Elife · 2021 · PMC8683079 · PMID 34913437

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clearly significantno p-value reported

How are the Orai1 localization results in 6D/E and 6G related? While the effects of C143A on SOCE, NFAT activation and IL-2 production are clearly significant, effects on the IS (TCR and actin accumulation) are not.

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