Previous studies of R134G force development in porcine skinned cardiac muscle fibers or in vitro actomyosin ATPase activity each detected small decreases in calcium sensitivity that did not reach statistical significance ( Hershberger et al. , 2009 ; Gangadharan et al. , 2017 ).
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A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding.
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