Similar to the findings in the nasal turbinates, the mean titers of B/HPIV3/S and B/HPIV3/S-2P (5.0 log 10 and 4.4 log 10 PFU/g) were lower than those of the B/HPIV3 empty vector on day 3, although the difference between B/HPIV3 and B/HPIV3/S in the lungs did not reach statistical significance.
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A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters.
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