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The activation fragment of PAR2 is elevated in serum from patients with rheumatoid arthritis and reduced in response to anti-IL6R treatment.

Sci Rep · 2021 · PMC8688421 · PMID 34930943

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In our study PRO-PAR2 was significantly increased in RA patients, while a numeric increase was observed in OA patients, which did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.