Intra-Tumor Heterogeneity of Colorectal Cancer Necessitates the Multi-Regional Sequencing for Comprehensive Mutational Profiling.

Cancer Manag Res · 2021 · PMC8689048 · PMID 34949941

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a clear trendno p-value reported

Meanwhile, a clear trend of correlation between worse differentiation and higher VAF was found, possibly suggesting that poor differentiation was related to high clonal evolution and high expansion of mutations.

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