Smad3 deficiency improves islet-based therapy for diabetes and diabetic kidney injury by promoting β cell proliferation <i>via</i> the E2F3-dependent mechanism.

Theranostics · 2022 · PMC8690916 · PMID 34987651

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showed a trendno p-value reported

Although db/db mice receiving Smad3WT islet transplantation showed a trend decrease of RBG and FBG compared with the sham-operated db/db mice, db/db mice transplanted with the equivalent dose of Smad3KO islets showed a significant decrease in RBG and FBG (Figure 3 A and B).

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