Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory.

The results showed a trend toward increased IFN-γ and TNF-α levels in tumors following therapy with MeVac αmPD-L1 or MeVac αmPD-1 in comparison with mock treatment, while in the MeVac IgG1-Fc and MeVac IgG-Fc C.m. groups, the levels of these cytokines remained comparable with mock ( Figures 4 B and 4C).

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