Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease.

Participants who experienced three or more AECOPDs during follow-up demonstrated DNAmTL accelerated ageing compared to those who did not experience any or only one AECOPD, and there was a significant trend across DNAmTL groups ( P = 8 × 10 –04 ) (Fig. 2 b).

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Although the Cox’s global test for the probability of mild exacerbations was borderline significant (Global test P = 0.05 ), the comparison between the short and long DNAmTL showed that short DNAmTL was associated with a greater probability of mild AECOPD over time ( P = 0.03 ) compared to long DNAmTL.

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