Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19.

Sci Rep · 2021 · PMC8695574 · PMID 34937861

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a negative trendno p-value reported

The increased AT1R levels after LOS treatment could be due to either a negative trend or non-responsiveness to LOS treatment at the given dose.

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a positive trendno p-value reported

We observed a positive trend between AT2R and ACE2 levels (Fig. 4 B), suggesting the activation of AT2R after LOS treatment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.