Altered Steroidome in Women with Gestational Diabetes Mellitus: Focus on Neuroactive and Immunomodulatory Steroids from the 24th Week of Pregnancy to Labor.

Biomolecules · 2021 · PMC8698588 · PMID 34944390

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an increasing trendno p-value reported

The prevalence of GDM is about 15–20% of pregnancies worldwide, with an increasing trend mostly linked to accelerating obesity [ 1 ].

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did not reach statistical significanceno p-value reported

Δ 4 Steroids From the Δ 4 pregnanes (seven analytes), the levels of two steroids (conjugated 17α,20α-dihydroxy-4-pregnen-3-one and 20α-dihydroprogesterone) were lower in the GDM+ group, while the differences in levels of five steroids (progesterone, 17-hydroxyprogesterone, 17α,20α-dihydroxy-4-pregnene-3-one, conjugated 20α-dihydroprogesterone) did not reach statistical significance ( Table 1 and Table S1 ).

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