The Neuropeptide VIP Limits Human Osteoclastogenesis: Clinical Associations with Bone Metabolism Markers in Patients with Early Arthritis.

Biomedicines · 2021 · PMC8698638 · PMID 34944693

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a clear trendno p-value reported

We detected a clear trend in the reduction of integrin β3 subunit mRNA level, which is concordant with our findings since the ITGB3 gene is a direct target of the VIP-negatively regulated NFATc1 transcription factor [ 64 ].

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