<i>TERT</i> Promoter Mutations Increase Sense and Antisense Transcription from the <i>TERT</i> Promoter.

Yet, although TERTp-luciferase was increased by each of the mutations, this trend did not reach statistical significance when the region encompassing exon 1 + intron 1 + 38 bp of exon 2 was present, in both HEK293T cells and in HeLa cells, illustrating the strong transcriptional repression exerted by intron 1 + exon 1 + 38 bp of exon 2.

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