They found that a high number of nitric oxide synthase 2 (INOS+) M1-like macrophages, both inside the tumor and at the invasive margins, was significantly associated with better OS, whereas the presence of CD163+ M2-like macrophages, inside the tumor, showed a trend toward poor prognosis [ 46 ].
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Impact of Immune Cell Heterogeneity on HER2+ Breast Cancer Prognosis and Response to Therapy.
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