Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like.

In VAT of HFD mice, hormone-sensitive lipase (HSL) and glucose transporter type 4 (Glut4) mRNA levels were significantly decreased, whereas mRNA expression levels of adipose triglyceride lipase (ATGL), adiponectin, peroxiredoxin 3 (Prx3), and uncoupling protein 1 (UCP1) showed a decreasing trend when compared with NCD mice ( Figure 2 G).

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The protein level of NLRP3 showed a trend toward upregulation in response to LPS and ATP in the HFD group when compared with the NCD group; however, this effect was not significant ( Figure 5 E).

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