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Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients.

Genes Immun · 2022 · PMC8703210 · PMID 34952932

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showed a trendno p-value reported
The data showed a trend toward a lower production of IFNα as well as IFNγ proteins in patients carrying LOF TLR7 variants.

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