An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade.

J Immunother Cancer · 2021 · PMC8705214 · PMID 34949694

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showed a trendno p-value reported

The combination therapy showed a trend of smaller tumor volume than mice treated with VV-scFv-TIGIT or αPD-1 alone ( figure 7B ).

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