Leptomeningeal disease and brain control after postoperative stereotactic radiosurgery with or without immunotherapy for resected brain metastases.

In the univariate analysis, no factors were associated with the development of LMD, including histology (NSCLC vs melanoma), size of lesion (≥3 cm vs <3 cm), type and timing of immunotherapy, number of BM, location (posterior fossa vs supratentorial location), proximity to the pial surface (<1 cm), and en bloc vs piecemeal resection; however, location in the posterior fossa (p=0.1) and en bloc resection (p=0.07) showed a trend toward reduced risk of LMD: the 1-year rates were 24% and 14%, respectively, for posterior fossa lesions versus other locations, and 26% and 13%, respectively, with piecemeal resection versus en bloc resection.

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