Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib.

Moreover, we observed that, during follow-up, patients who developed remission showed a trend of an increased expression of the examined genes ( p = 0.06 in the case of SDHB, and p = 0.15 in the case of PKM2), whereas the others showed a minor decrease in gene expression, although this was not statistically significant ( Table 1 ). 3.3.

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Bivariate correlation analyses, using Pearson’s correlation coefficients for baseline expressions of the aforementioned genes with the clinical parameters, revealed a negative correlation between PKM2 gene expression and the ΔDAS28 after 3 months of follow-up (r = −0.433, p = 0.02) and only a nonsignificant trend with regard to SDHB expression (r= −0.274, p = 0.17).

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Moreover, we observed that, during follow-up, patients who developed remission showed an increasing trend in the expression of the examined genes, whereas the others showed some decreases in gene expression, although this was not statistically significant.

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