Human Cytomegalovirus Replication and Infection-Induced Syncytia Formation in Labial, Foreskin, and Fetal Lung Fibroblasts.

In summary, while the universal ability of fibroblasts to support CMV infection may suggest that organotypic properties are unlikely to be relevant to CMV pathogenesis in vivo, our data show that fibroblasts derived from different organs have significantly different properties, some of which, such as the ability to support cell–cell fusion at late times pi, may be quite significant for CMV spread, transmission, and escape from antibody detection, with direct effects on the infection-associated disease and vaccine efficacy.

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