Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods.

In the OF test, AP2γ KO mice showed a trend toward a decrease in the distance traveled in the anxiogenic center of the arena ( P = 0.05, Figure 4B ), with no changes in locomotor activity as denoted by similar average velocity ( Figure 4—figure supplement 1A ).

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Yet, we believe it is worthy to note that adult AP2γ KO mice present a trend towards significance ( p = 0.08) for cognitive deficits in a similar task when challenged to recognize a change in the location of the object.

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