The energy of the recoil effect may be significant enough to cause the breakage of the bond between the daughter radionuclide and the ligand.
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The sentences
In the Indian series by Yadav and colleagues, PFS and OS were shorter in patients with a history of prior 177 Lu-PSMA therapy compared with patients without; the difference did not reach statistical significance, however, probably due to the small study population [ 77 ].