Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse <i>LMNA</i> Mutations.

Front Physiol · 2021 · PMC8716763 · PMID 34975533

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Interestingly, compared to the controls, M1I-, R335Q- and R541C- LMNA mixture monolayer showed a trend towards exaggerated electrical perturbations over iCMs alone, including prolonged beat period and FPDc, slower conduction velocity accompanied by increased excitation-contraction delay ( Figures 8B – E ).

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