Quantification of T-cell dynamics during latent cytomegalovirus infection in humans.

Interestingly, the expression of CD57, KLRG-1, and CD28 show moderate and highly significant correlations with the estimated production rates ( r = -0.6576, r = -0.6741, r = 0.7088, respectively; for all markers P < 0.0001) ( Fig 5 ).

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Although the difference in estimated production/loss rates of CD4 + T EM/EMRA cells in CMV+ versus CMV- individuals did not reach statistical significance, the observed trend for a lower turnover rate of CD4 + T EM/EMRA cells in CMV+ individuals ( Fig 3C ) is in line with our results based on Ki-67 and Bcl-2 expression ( Fig 2A ).

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