High-Throughput Sequencing of BACHD Mice Reveals Upregulation of Neuroprotective miRNAs at the Pre-Symptomatic Stage of Huntington's Disease.

At 2 months of age, 5 miRNAs (miR-409-5p, miR-133a-3p, miR-146b-5p, miR-449a-5p, miR-486-5p) were confirmed to be significantly down or up-regulated in BACHD mice, comparing to WT controls, while 2 other miRNAs (miR-100-5p and miR-7a-5p) showed a similar trend of down- or up-regulation as that of sequencing data, although these differences did not reach statistical significance in the case of RT-qPCR results ( Figure 2B ).

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