The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.

Histologically, improvements in the renal pathology of anti-CD6–treated MRL/lpr mice did not reach statistical significance, though decreases were observed in scores for endocapillary hypercellularity, glomerular injury, and crescent formation ( Figure 6B ).

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The improvement in kidney function was also accompanied by improvements in renal pathology, with a significant decrease in glomerular pathology and a decreasing trend in tubular pathology ( Figure 7, E–G ).

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