75 Additionally, ovarian cancer patients simultaneously with a low serum exosomal miR-484 and a high serum CA125 expressions showed a trend toward worse clinical outcomes. 74 The upregulation of serum exosomal lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in EOC patients was associated with an advanced and metastatic phenotype of EOC, which potentially predicted poor overall survival for EOC patients. 76 Therefore, the nucleic acids carried by blood exosomes of ovarian cancer patients may act as biomarkers for predicting their clinical outcomes.
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Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers.
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