only marginally significantP = 0.049
8 In the FREEDOM study, the benefit with CABG over PCI for all-cause death at 5 years was only marginally significant ( P = 0.049), 4 however, considering that the trial was not powered for all-cause death, this result could be considered hypothesis-generating. 15 In the FREEDOM Follow-On study, 16 which extended follow-up in 943 of the original 1900 patients cohort, the estimated rate of mortality at 8 years was 23.7% and 18.7% in the PCI-DES and CABG group, respectively (unadjusted HR: 1.32, 95% CI: 0.97, 1.78, P = 0.076), with the HR remaining unchanged after adjustment.