After intravenous administration, the Amicon Ultra Centrifugal Filter separated group displayed a significantly higher ( p < 0.0001) brain concentration (ng/g brain) compared to the brain homogenate group for cTfRMAb-EPO, and a similar trend was seen for the cTfRMAb-N292G-EPO fusion protein, though these values did not reach statistical significance ( Fig. 3 A).
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The concentration of brain homogenates with the Amicon Ultra Centrifugal filters.
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