In addition, significant differences in the histological grade were observed across the 4 metabolic subtypes ( P = 8.95e-5) and quiescent tumors tended to exhibit lower histological grade and less advanced pathological stage, although the latter did not reach statistical significance ( P = 0.087) (Fig. 2 D-E).
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Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration.
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0.0870
0.0900
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marginally significantP = 0.09
The survival benefit of quiescent tumors in comparison to mixed tumors was observed in muscle-invasive BCa (overall log-rank P = 0.011); however, the difference was marginally significant in non-muscle-invasive BCa (log-rank P = 0.09), probably due to the limited sample size.