Effect of dose, dosing intervals, and hypoxic stress on the reversal of pulmonary hypertension by mesenchymal stem cell extracellular vesicles.

Pulm Circ · 2021 · PMC8723172 · PMID 34987768

Europe PMC DOI

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a strong trendno p-value reported

not quite statistically significantno p-value reported

There was also a strong trend toward lower RVSP and RV/LV+S in SuHx-PH rats given MSC EV at 5 μg/kg, but the differences were not quite statistically significant.

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a nonsignificant trendno p-value reported

There was a nonsignificant trend toward higher RVSP and RV/LV+S at doses below 5 μg/kg ( Fig. 1 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.