Postnatal expression of the lysine methyltransferase SETD1B is essential for learning and the regulation of neuron-enriched genes.

It is therefore interesting to note that the genes affected in Setd1b cKO mice not only showed a broader H3K4me3 peak and higher expression when compared with the genes affected in Kmt2a (it has to be mentioned that this comparison failed to reach statistical significance, P = 0.1) or Kmt2b cKO mice but that also memory performance in the water maze training was more severely affected in Setd1b cKO mice when compared with mice lacking Kmt2a or Kmt2b .

also in 6,035 other papers

Consequently, the genes that concomitantly exhibited decreased H3K4me3 levels and were downregulated in Setd1b cKO mice displayed significantly broader H3K4me3 peaks at the TSS (Fig 5B ) and were expressed at higher levels under basal conditions when compared with the genes controlled by Kmt2a or Kmt2b (Fig 5C ; Dataset EV22 and 23 ), although it has to be mentioned that the direct comparison of the expression values in Setd1b and Kmt2a cKO mice failed to reach significance (Fig 5C ; Dataset EV22 and 23 ).

also in 4,113 other papers