Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma.

Although the efficacy of Prexasertib in combination with Venetoclax in DE cell lines was not affected by baseline γH2AX and 8-OHdG levels, cell lines with low levels of γH2AX and 8-OHdG showed a trend toward a decreased sensitivity to single-agent Venetoclax (Figure S8B-G ).

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