Bile acid homeostasis in female mice deficient in <i>Cyp7a1</i> and <i>Cyp27a1</i>.

Ibabp , which is positively regulated by FXR activation showed robust increases in all GW4064 treated groups, but failed to reach significance due to large variation. 4 Discussion There are currently a multitude of FDA approved therapies that exploit aspects of FXR and BA signaling, including the use of individual BA, such as ursodeoxycholic acid (UDCA) for the treatment of primary biliary cholangitis or CDCA replacement therapy for the treatment of cerebrotendinous xanthomatosis, a human genetic diseases due to CYP27A1 mutation.

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WT mice displayed a significant increase in Ostβ expression, while knockout groups that had higher basal levels showed a trend for induction with DKO mice being induced 2.25-fold as compared to DKO vehicle treated mice.

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