In both the UTSW and Global cohort, there was a near-significant trend association with greater OS among patients with late-onset irAE compared to patients with early-onset irAE by the 6-month landmark time (UTSW cohort, HR 0.55, 95% CI, 0.25–1.24; P = .15; Global cohort, HR 0.49, 95% CI, 0.26–0.91; P = .06) (Supplementary Figure 2 ).
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Association between immune-related adverse event timing and treatment outcomes.
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