Increased circulating butyrate and ursodeoxycholate during probiotic intervention in humans with type 2 diabetes.

BMC Microbiol · 2022 · PMC8742391 · PMID 34996347

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a possible trendno p-value reported

Although there appears to be a possible trend for a within-group increase in (G-)CDCA, we found only limited evidence for increases in the substrates from which UDCA is typically derived (CDCA, lithocholic acid, all between-group p > 0.19), suggesting the increase is driven by increased activity of UDCA-generating microbes.

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did not reach statistical significanceno p-value reported

Participants randomized to WBF-011 showed an encouraging increase in fecal butyrate concentration that was not observed in participants receiving placebo, although the increase did not reach statistical significance.

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