ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

J Exp Clin Cancer Res · 2022 · PMC8742403 · PMID 34998404

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We also determined the ECAR to assess glycolytic stress and found that 5-FU-R cells showed a trend toward a higher ECAR (Fig. 3 e).

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