Myeloid cell-mediated targeting of LIF to dystrophic muscle causes transient increases in muscle fiber lesions by disrupting the recruitment and dispersion of macrophages in muscle.

We observed a reduction of more than 20% in the proportion of macrophages expressing CCL2 in muscles of 1-month-old LIF/ mdx mice and observed a strong trend for the same effect at the 3-month time-point ( Fig. 4E ).

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