Challenge accepted: uncovering the role of rare genetic variants in Alzheimer's disease.

Mol Neurodegener · 2022 · PMC8744312 · PMID 35000612

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nominally significantno p-value reported

Even though no individual rare variants in the MS4A gene cluster and ABCA1 have reached consistent statistical significance in association with the risk of AD, a higher, nominally significant burden of rare coding variants has been found in controls compared to AD in both cases.

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