Global prognostic impact of driver genetic alterations in patients with lung adenocarcinoma: a real-life study.

Among LAC patients with additional tissue section available for next-generation sequencing (NGS)-based analysis, 26/193 (13.5%) patients found positive for even low-rate EGFR-T790M mutated alleles at baseline were associated with a highly significant lower survival in comparison to those without (8.7 vs. 47.4 months, p < 0.0001).

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BRAF mutations were more common in males and smokers, but these differences did not reach statistical significance, while MET amplifications were significantly more frequent in females than in males (Table 2 ).

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