Rapid genome editing by CRISPR-Cas9-POLD3 fusion.

Although the POLD3 fusion showed a trend for improvement in both cell types, the benefit is less pronounced than in the model RPE-1 and fibroblast cells possibly due to cell-type-specific differences in cell proliferation rate and DNA damage and repair signaling ( Miyaoka et al., 2016 ).

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Combined, these two facts make this paper a highly significant contribution to the genome editing field.

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