a clear trendP = 0.05
Notably, significant upregulation of the keratinocyte terminal differentiation marker filaggrin (FLG; + 308%; P < 0.001) and a clear trend towards an increase (+ 132%; P = 0.05) in transcript levels of the epidermal differentiation complex protein loricrin (LOR) was observed in skin from SGC707-treated mice (Fig. 4 C).