On-demand Versus Continuous Maintenance Treatment of Gastroesophageal Reflux Disease With Proton Pump Inhibitors: A Systematic Review and Meta-analysis.

J Neurogastroenterol Motil · 2022 · PMC8748841 · PMID 34980685

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did not reach statistical significanceno p-value reported

difficile infection in PPI group (9 cases in 8791) compared to placebo group (4 cases in 8807), which did not reach statistical significance due to very few number of cases in either group (OR, 2.26, 95% CI, 0.70-7.34). 28 According to available evidences, the Food and Drug Administration and Prevention announced that C. difficile diarrhea may be associated with PPI use.

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