Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.

In contrast, a similar analysis of genes induced in MAPT P301S astrocytes did not achieve significance at any p value cut-off (Fig. 2B , right).

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We employed a fear conditioning memory test in which we observed a deficit at 9 months (a 7 month cohort showed a trend towards a deficit that was not significant, Supplementary Fig. 9H ).

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